A Clean Slate chronicles the days of Kelly McGraw, a Chicago woman who suddenly can't remember the last five months of her life, a time when she was dumped by her soon-to-be fiance and laid off by the company she thought would make her partner. Overwhelmed and confused but otherwise feeling wonderful, she begins to realize that she has a clean slate in life. She can do anything she wants, go anywhere she wants, be anything she wants. But what, exactly, does she want?

Follow Kelly on a journey that includes her search to discover what caused her memory loss, an internship with a bad-boy British photographer, a Caribbean photo shoot, her boyfriend's desire to come crawling back and, eventually, a brutal discovery that will cause her to reevaluate both her old and new lives.